E-cadherin loss is responsible for the inherently discohesive phenotype associated with ILCs, and changes at the genomic level account for this loss. Typically, ILC tumours display features associated with a good prognosis, being low grade and oestrogen receptor positive however, the tumour can be highly metastatic and several studies demonstrate that the overall long-term outcome for patients diagnosed with ILC may be similar or worse than for patients diagnosed with IC-NST. Invasive lobular carcinoma (ILC) is the most common ‘special’ type of breast cancer and presents with a distinct morphology and clinical behaviour compared with invasive carcinoma of no special type (IC-NST).
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